Cutting Through the Noise; A Critical Look at Vitamin D’s role in IVF Success in Women Over 40-SWOT Analysis and Debate

Elsawy, Aya; Maghraby*, Hassan

doi:10.21608/jrme.2025.373429.1041

Cutting Through the Noise; A Critical Look at Vitamin D’s role in IVF Success in Women Over 40-SWOT Analysis and Debate

Document Type : Debate

Authors

Aya Elsawy ¹^{, 2}
Hassan Maghraby* ¹^{, 2}

¹ Obstetrics and Gynecology department, Faculty of Medicine, Alexandria University, Egypt.

² Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt.

10.21608/jrme.2025.373429.1041

Abstract

Background:
Infertility remains a significant concern for many women worldwide, especially as they age. Women over 40 face additional challenges regarding fertility due to biological factors, including decreased ovarian reserve, affection of endometrial receptivity, changes in hormonal balance, and aneuploidies. Vitamin D has been increasingly recognized as a potential factor influencing fertility and IVF outcomes; however, its role in women over 40 undergoing IVF remains unclear.

Objective:
To conduct a SWOT analysis on the use of Vitamin D in women over 40 undergoing IVF, examining its strengths, weaknesses, opportunities, and threats, along with a debate clarifying perspectives of both advocates and critics regarding vitamin D supplementation.

Methods:
A comprehensive analysis of the current literature and expert opinions on Vitamin D supplementation in women over 40 undergoing IVF was conducted, focusing on its potential benefits, drawbacks, and applications.

Results:
The analysis revealed potential benefits of Vitamin D supplementation, including improved embryo quality and increased pregnancy rates. However, drawbacks and challenges were also identified, including variability in individual responses and potential interactions with other medications.

Conclusion:
The use of Vitamin D in women over 40 undergoing IVF is a complex issue, with both potential benefits and drawbacks. While emerging evidence supports the potential benefits of vitamin D in enhancing IVF outcomes in women over 40, further clinical studies are needed to define its precise role, optimal dosage, and the mechanisms by which it influences fertility..Further discussion and research are needed to fully understand its role and to inform evidence-based practice.

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