Unlocking Fertility Potential in Women 40+; Can Q10 Improve Egg Quality?

Document Type : Editorial

Author

Obstetrics and Gynecology department, Alexandria University, Egypt.

Abstract

Could CoQ10 hold unexpected promise for ovarian rejuvenation? Could it be the "bridge" between the "bench" and the "bed" for millions navigating the intersection of biology and time."
Reproductive aging in women over 40 is marked by declining oocyte quality driven by mitochondrial dysfunction, oxidative stress, and chromosomal instability. At the heart of this decline lies aneuploidy—a leading cause of age-related infertility and miscarriage—rooted in failures of meiotic cohesion, spindle assembly, and DNA repair. Emerging preclinical research now spotlights Coenzyme Q10 (CoQ10), a mitochondrial electron transporter and antioxidant, as a potential mitigator of these age-associated defects. It offers the potential to restore ATP fuel to spindles, shield cohesion from oxidative sabotage, and perhaps even slow the telomeric clock. Could this molecule hold a key to rewriting the narrative of reproductive aging? The data, though nascent, ignite a question; could CoQ10 bridge the gap between the "bench" and the "bed" for women over 40?

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Journal of Reproductive Medicine and Embryology
Volume 1, Issue 4
February 2025
Pages 214-216

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