PGT-A: Yes versus No

Saleh, Hisham; Adel, Nehal

doi:10.21608/jrme.2024.307483.1016

PGT-A: Yes versus No

Document Type : Debate

Authors

Hisham Saleh ¹^{, 2}^{, 3}
Nehal Adel ³^{, 4}

¹ Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt. Egypt.

² Agial Fertility Center, Agial Hospital, Alexandria, Egypt.

³ Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt.

⁴ Madina ICSI Fertility Center, Madina women's hospital, Alexandria, Egypt.

10.21608/jrme.2024.307483.1016

Abstract

The goal of In Vitro Fertilisation is a healthy full-term fetus. Still ART remains inefficient. The selection of embryos for transfer is based mainly on morphology. Morphology alone cannot select the embryo with the highest implantation potential. About 60% of early human embryos are aneuploid, and it increases dramatically with increasing maternal age.Embryo aneuploidy is the leading cause of implantation failure and miscarriage after IVF.
Aneuploidy screening through taking a biopsy from the morphologically normal embryos & analysis of the embryo DNA allows to deselect embryos with abnormal chromosomal number. Aneuploid embryos are unable to self-correct. The proposed benefit is to improve embryo selection over morphological assessment to enhance the likelihood that a transferred embryo would result in a healthy live birth.

Despite its worldwide use, PGT-A has faced many challenges and concerns from opponents regarding its value, accuracy, validity, cost effectiveness. Several fundamental questions must be answered in this regard.

Keywords