Background: The optimization of clinical pregnancy rates following assisted reproductive technologies relies on various factors, including embryo quality and the implantation process. Recent research has focused on the role of vitamin D in enhancing implantation during intracytoplasmic Sperm Injection (ICSI). Objective: The primary objective of this study was to investigate the impact of vitamin D level on implantation, with secondary objectives examining the associations between vitamin D levels and clinical pregnancy rates and live birth rates. Materials and Methods: A quasi-experimental study was conducted at the Libyan National Fertility Centre and involved 60 infertile women. Each participant underwent two ICSI cycles, with the first cycle using insufficient vitamin D levels and the second using sufficient vitamin D levels. Excluded patients due to polycystic ovaries, endometriosis, premature ovarian failure, and male factor infertility. The Endocrine Society defined vitamin D insufficiency as levels <20 ng/ml. Results: Patients were assessed at two phases based on vitamin D levels—insufficient and sufficient phase. Clinical pregnancy rates were 31.67% and 61.67%, respectively (p<.016). The endometrial configuration, including thickness and pattern, positively correlated with sufficient vitamin D levels (p<.027). However, no statistically significant difference in oocyte quality was observed. Conclusion: The findings of this study affirm that vitamin D levels have a positive predictive value for ICSI outcomes. This study recommends vitamin D supplementation among infertile patients to enhance CPR and LBR.
Elfortia, I., Andisha, A., Eljabu, H., & Zablah, A. (2024). The role of vitamin D in determining Intra-cytoplasmic sperm injection outcome: A Quasi-experimental study. Journal of Reproductive Medicine and Embryology, 1(1), 42-47. doi: 10.21608/jrme.2024.258978.1000
MLA
Ismail Elfortia; Awatif Andisha; Hanan Eljabu; Asma Zablah. "The role of vitamin D in determining Intra-cytoplasmic sperm injection outcome: A Quasi-experimental study", Journal of Reproductive Medicine and Embryology, 1, 1, 2024, 42-47. doi: 10.21608/jrme.2024.258978.1000
HARVARD
Elfortia, I., Andisha, A., Eljabu, H., Zablah, A. (2024). 'The role of vitamin D in determining Intra-cytoplasmic sperm injection outcome: A Quasi-experimental study', Journal of Reproductive Medicine and Embryology, 1(1), pp. 42-47. doi: 10.21608/jrme.2024.258978.1000
VANCOUVER
Elfortia, I., Andisha, A., Eljabu, H., Zablah, A. The role of vitamin D in determining Intra-cytoplasmic sperm injection outcome: A Quasi-experimental study. Journal of Reproductive Medicine and Embryology, 2024; 1(1): 42-47. doi: 10.21608/jrme.2024.258978.1000
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